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With few exceptions, investors should run screaming from any stock quoted on the Pink Sheets. But not every over-the-counter stock is a dud. In fact, some of them are top-notch global companies. Here are some major companies listed on the Pink Sheets that are outperforming the S&P 500.

The pharmaceutical sector was on fire Monday, with successful trials, FDA approvals, and some deal action. So far, Tuesday is shaping up to be similar. Big pharma takes its hits for questionable practices. But on days like these, we remember the enormous value and contributions that drug companies...

Stocks around the world are under pressure as a form of swine flu spread beyond Mexico where it has killed over 80 people and infected more than 1,300 others. Because of the nature of the disease there are concerns that it could cause a pandemic, crippling international travel and undermining...