OrexigenTherapeutics

Orexigen jumped over 25% in premarket trading after announcing an exclusive partnership agreement potentially worth over $1 billion with Japan's Takeda Pharmaceutical to develop and commercialize Contrave, Orexigen's promising obesity drug.

On NBC's hit series The Biggest Loser, obese contestants must huff and puff through weeks of endless push-ups, sit-ups and treadmill sprints in hopes of shedding more pounds than their rivals. But with all the sweat and tears required to go from fat to fabulous, many other plus-sized people are...