When considering any stock for your portfolio, don't be swayed by just the positives. Examine its pros and cons, and decide whether it's possible upside outweighs its risks. Let's take a look at Affymax today and see why you might want to buy, sell, or hold it.

Founded  in 2001 and based in California, Affymax sports a market capitalization of about $850 million, making it a small-cap company. It's a biopharmaceutical enterprise, known for its Omontys injections that treat anemia in some dialysis patients. Its stock has more than tripled  over the past year, leading some to want to jump into it and others to be wary.

Buy
One reason to consider buying Affymax is its business. With the world's population growing, getting older, and living longer, demand for health-care products and services is likely to remain in demand.


Its business is growing, as third-quarter revenue rose 3% and net losses came in a little smaller than expected. Much of that revenue, $10.4 million out of the $13.6 million total, came from its Omontys partner, Takeda Pharmaceuticals.

Speculators might be interested in Affymax as a possible acquisition target, but it's rarely smart to base investment decisions on speculation.

Sell
The company's valuation  is a concern, which isn't surprising given its surge over the past year. It has no price-to-earnings ratio, as it has no earnings yet, and its price-to-sales and price-to-book value numbers are much higher than the company's five-year averages.

Its financial figures have been a lumpy, too, with revenue rising from $44 million in 2007 to $115 million in 2009 and then back down to $48 million in 2011, and up to $83 million on a trailing-12-month basis. It's not quite fair to compare the past to the present, though, as Omontys has only recently been approved and on the market.

Its share count has more than doubled since 2007, too, shrinking the value of existing shares via dilution. Cash flow  has long been negative, but at least debt is modest. Recent cash levels look like they can support cash burn for a year or two, at least.

Meanwhile, Affymax does have competition, such as from Amgen , which has contracts in place with dialysis providers DaVita and Fresenius Medical Care to distribute its drug Epogen. Affymax also has arrangements with Fresenius and others and is working to boost its market share. Omontys has a significant advantage over Omontys in that it's a once-a-month treatment, versus twice-a-week for Epogen. It's also strategically priced lower than Epogen.

Finally, unlike many other biotech outfits, Affymax doesn't have a pipeline full of new drugs in development. It is researching more uses for Omontys, though.

Hold (off)
Given the reasons to buy or sell Affymax, it's not unreasonable to decide to just hold off on it. You might want to wait for its losses to turn into gains, and for its revenue to ramp up. You might want to see more products approved and selling, as well.

You might also check out some other interesting biotech or pharmaceutical companies, to see if they inspire more confidence than Affymax. Spectrum Pharmaceuticals , for example, actually has products on the market, such as its colorectal cancer drug, Fusilev. It's also sporting an attractive valuation, despite some concerns, such as competition.

Antares Pharma may also be of interest, also with products on the market, such as ones featuring its needle-less injection technology and drug-delivering gels. It has been growing briskly, and its stock may have gotten ahead of itself too.

The verdict
I'm holding off on Affymax for now. Everyone's investment calculations are different, though. Do your own digging and see what you think. The company may perform spectacularly in the coming years, but remember that there are plenty of compelling stocks out there.

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The article Buy, Sell, or Hold: Affymax originally appeared on Fool.com.

Longtime Fool contributor Selena Maranjian, whom you can follow on Twitterhas no positions in the stocks mentioned above. The Motley Fool has no positions in the stocks mentioned above. Try any of our Foolish newsletter services free for 30 days. We Fools don't all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.

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